Apigenin: A Natural Flavonoid with Therapeutic Potential in Cancer Mechanisms, Physiochemical and Biopharmaceutical Properties, and Future Perspectives

Jakia  Sultana; Most. Israt Jahan  Oni; Md.  Shadin

doi:10.71193/jpci.20250007

Authors

Jakia Sultana Department of Pharmacy, Comilla University, Bangladesh Author https://orcid.org/0009-0005-7109-4627
Most. Israt Jahan Oni Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0002-1236-5501
Md. Shadin Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0000-1587-2838

DOI:

https://doi.org/10.71193/jpci.20250007

Keywords:

Apigenin, Anti-Cancer Activity, Flavonoids, Mechanism of action, Pharmacokinetic

Abstract

Apigenin (APG), a flavonoid found in various fruits, vegetables, and herbs, has gained attention for its anticancer properties. This review summarizes the various botanical origins, physiochemical & biopharmaceutical properties of APG and its anticancer activity across different cancer types by investigating its effects on various cancer cell lines, underlying mechanisms, and effective doses. Studies indicate that APG exerts its anticancer effects by inhibiting cell proliferation, inducing apoptosis, and promoting autophagy. Additionally, APG has been shown to trigger necroptosis in cancer cells, contributing to its anticancer potential. The data highlights the ability of APG to suppress cancer cell growth, migration, and invasion, with varying effective doses depending on the cancer type. This review exhibits the potential of APG as a promising anticancer agent, revealing its therapeutic applications. However, further research, particularly clinical trials, is needed to optimize dosing and assess its full therapeutic potential in cancer treatment

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Author Biographies

Jakia Sultana, Department of Pharmacy, Comilla University, Bangladesh

Jakia Sultana, a Pharmacy graduate from Comilla University, Kotbari, Comilla, Bangladesh, is passionate about phytochemicals and drug discovery. Her research focuses on analyzing plant-based compounds for potential therapeutic applications.
Most. Israt Jahan Oni , Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh

Most. Israt Jahan Oni is a B. Pharm. student in Pharmacy at GSTU, Gopalganj 8100, Bangladesh. She is also working as Junior Executive Researcher at BioLuster Research Center Ltd., Dhaka, Bangladesh. She is mainly interested in cancer, neurology, computational drug design, in silico studies and natural compounds.
Md. Shadin, Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh

Md. Shadin is a B.Pharm. student in Pharmacy under the Faculty of Life Science at GSTU, Gopalganj 8100, Bangladesh. He is also working as Junior Executive Researcher at BioLuster Research Center Ltd., Dhaka, Bangladesh. He is mainly interested in cancer, neurology, computational drug design, in silico studies, vaccine designing and natural compounds.