Anticancer Activity of Scutellarein Against Several Cancer Types with Possible Mechanisms: A Mini Review

Imam Hossen  Rakib; Rakib  Hossan; Md. Sakib Al Hasan; Noshin Tasnim   Yana; Fowjia Ahmed  Safa; Umme Habiba Sumaya

doi:10.71193/jpci.20250005

Authors

Imam Hossen Rakib Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0003-2552-8952
Rakib Hossan Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author
Md. Sakib Al Hasan Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0004-7560-4041
Noshin Tasnim Yana Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author
Fowjia Ahmed Safa Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0002-8189-1134
Umme Habiba Sumaya Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0000-2291-766X

DOI:

https://doi.org/10.71193/jpci.20250005

Keywords:

Scutellarein, Anti-cancer, Proliferation, Flavone

Abstract

Scutellarein (STN), a bioactive flavone found in various medicinal plants such as Scutellaria baicalensis and Scutellaria lateriflora. It has a variety of pharmacological actions, including anticancer properties. This study explores STN’s anticancer activity against various cancer cell lines. A literature review was conducted using databases such as PubMed, ScienceDirect, and Google Scholar, focusing on research evaluating STN’s anticancer efficacy. The results showed that STN has significant anticancer properties against various types of cancer, such as blood, colon, colorectal, gastric, liver, lung, ovarian, and renal cancers. STN reduces cell growth by cell cycle arrest, triggers apoptosis through caspase activation, and inhibits metastasis by suppressing mitochondrial membrane potential (MMP) and epithelial mesenchymal transition (EMT) markers. It modulates important pathways such as ERK, Wnt/β-catenin, and PI3K/Akt/NF-κB. Together, these systems prevent the growth and metastasis of cancer cells. The compound has exhibited prominent cytotoxicity in diverse cancer cell lines.

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References

Abotaleb, M., Samuel, S. M., Varghese, E., Varghese, S., Kubatka, P., Liskova, A., & Büsselberg, D. (2018). Flavonoids in Cancer and Apoptosis. Cancers, 11(1), 28. https://doi.org/10.3390/cancers11010028 DOI: https://doi.org/10.3390/cancers11010028

Berger, A. M., Abernethy, A. P., Atkinson, A., Barsevick, A. M., Breitbart, W. S., Cella, D., Cimprich, B., Cleeland, C., Eisenberger, M. A., Escalante, C. P., Jacobsen, P. B., Kaldor, P., Ligibel, J. A., Murphy, B. A., O'Connor, T., Pirl, W. F., Rodler, E., Rugo, H. S., Thomas, J., & Wagner, L. I. (2010). NCCN Clinical Practice Guidelines Cancer-related fatigue. Journal of the National Comprehensive Cancer Network: JNCCN, 8(8), 904–931. https://doi.org/10.6004/jnccn.2010.0067 DOI: https://doi.org/10.6004/jnccn.2010.0067

Bontempo, P., De Masi, L., & Rigano, D. (2023). Functional Properties of Natural Products and Human Health. Nutrients, 15(13), 2961. https://doi.org/10.3390/nu15132961 DOI: https://doi.org/10.3390/nu15132961

Cao, P., Liu, B., Du, F., Li, D., Wang, Y., Yan, X., Li, X., & Li, Y. (2019). Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways. Thoracic cancer, 10(3), 492–500. https://doi.org/10.1111/1759-7714.12962 DOI: https://doi.org/10.1111/1759-7714.12962

Cheng, C. Y., Hu, C. C., Yang, H. J., Lee, M. C., & Kao, E. S. (2014). Inhibitory effects of scutellarein on proliferation of human lung cancer A549 cells through ERK and NFκB mediated by the EGFR pathway. The Chinese journal of physiology, 57(4), 182–187. https://doi.org/10.4077/CJP.2014.BAC200 DOI: https://doi.org/10.4077/CJP.2014.BAC200

Deng, W., Han, W., Fan, T., Wang, X., Cheng, Z., Wan, B., & Chen, J. (2018). Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107, 1505–1513. https://doi.org/10.1016/j.biopha.2018.08.127 DOI: https://doi.org/10.1016/j.biopha.2018.08.127

Feng, Y., Zhang, S., Tu, J., Cao, Z., Pan, Y., Shang, B., Liu, R., Bao, M., Guo, P., & Zhou, Q. (2012). Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells. Leukemia & lymphoma, 53(12), 2456–2464. https://doi.org/10.3109/10428194.2012.693177 DOI: https://doi.org/10.3109/10428194.2012.693177

Gowda Saralamma, V. V., Lee, H. J., Raha, S., Lee, W. S., Kim, E. H., Lee, S. J., Heo, J. D., Won, C., Kang, C. K., & Kim, G. S. (2017). Inhibition of IAP's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein. Oncotarget, 9(5), 5993–6006. https://doi.org/10.18632/oncotarget.23202 DOI: https://doi.org/10.18632/oncotarget.23202

Griffiths, K., Aggarwal, B. B., Singh, R. B., Buttar, H. S., Wilson, D., & De Meester, F. (2016). Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention. Diseases (Basel, Switzerland), 4(3), 28. https://doi.org/10.3390/diseases4030028 DOI: https://doi.org/10.3390/diseases4030028

Ha, S. E., Kim, S. M., Vetrivel, P., Kim, H. H., Bhosale, P. B., Heo, J. D., Lee, H. J., & Kim, G. S. (2021). Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NF-κB Signaling through PTEN Activation in Hepatocellular Carcinoma. International journal of molecular sciences, 22(16), 8841. https://doi.org/10.3390/ijms22168841 DOI: https://doi.org/10.3390/ijms22168841

Han, T., Zhang, S., Wei, R., Jia, G., Wang, B., Xu, Q., Su, J., Jiang, C., & Jin, C. (2022). Synthesis and biological evaluation of scutellarein derivatives as neuroprotective agents via activating Nrf2/HO-1 pathway. Fitoterapia, 160, 105207. https://doi.org/10.1016/j.fitote.2022.105207 DOI: https://doi.org/10.1016/j.fitote.2022.105207

Hanahan D. (2022). Hallmarks of Cancer: New Dimensions. Cancer discovery, 12(1), 31–46. https://doi.org/10.1158/2159-8290.CD-21-1059 DOI: https://doi.org/10.1158/2159-8290.CD-21-1059

Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell, 144(5), 646–674. https://doi.org/10.1016/j.cell.2011.02.013 DOI: https://doi.org/10.1016/j.cell.2011.02.013

Lang, X., Chen, Z., Yang, X., Yan, Q., Xu, M., Liu, W., He, Q., Zhang, Y., Cheng, W., & Zhao, W. (2021). Scutellarein induces apoptosis and inhibits proliferation, migration, and invasion in ovarian cancer via inhibition of EZH2/FOXO1 signaling. Journal of biochemical and molecular toxicology, 35(10), e22870. https://doi.org/10.1002/jbt.22870 DOI: https://doi.org/10.1002/jbt.22870

Li, Y., Wang, J., Zhong, S., Li, J., & Du, W. (2020). Scutellarein inhibits the development of colon cancer via CDC4 mediated RAGE ubiquitination. International journal of molecular medicine, 45(4), 1059–1072. https://doi.org/10.3892/ijmm.2020.4496 DOI: https://doi.org/10.3892/ijmm.2020.4496

Lichota, A., & Gwozdzinski, K. (2018). Anticancer Activity of Natural Compounds from Plant and Marine Environment. International journal of molecular sciences, 19(11), 3533. https://doi.org/10.3390/ijms19113533 DOI: https://doi.org/10.3390/ijms19113533

Millimouno, F. M., Dong, J., Yang, L., Li, J., & Li, X. (2014). Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer prevention research (Philadelphia, Pa.), 7(11), 1081–1107. https://doi.org/10.1158/1940-6207.CAPR-14-0136 DOI: https://doi.org/10.1158/1940-6207.CAPR-14-0136

Noble, S., & Pasi, J. (2010). Epidemiology and pathophysiology of cancer-associated thrombosis. British journal of cancer, 102 Suppl 1(Suppl 1), S2–S9. https://doi.org/10.1038/sj.bjc.6605599 DOI: https://doi.org/10.1038/sj.bjc.6605599

Nurul Islam, M., Downey, F., & Ng, C. K. (2011). Comparative analysis of bioactive phytochemicals from Scutellaria baicalensis, Scutellaria lateriflora, Scutellaria racemosa, Scutellaria tomentosa and Scutellaria wrightii by LC-DAD-MS. Metabolomics, 7, 446-453. DOI: https://doi.org/10.1007/s11306-010-0269-9

Sang Eun, H., Seong Min, K., Ho Jeong, L., Vetrivel, P., Venkatarame Gowda Saralamma, V., Jeong Doo, H., Eun Hee, K., Sang Joon, L., & Gon Sup, K. (2019). Scutellarein Induces Fas-Mediated Extrinsic Apoptosis and G2/M Cell Cycle Arrest in Hep3B Hepatocellular Carcinoma Cells. Nutrients, 11(2), 263. https://doi.org/10.3390/nu11020263

Saralamma, V. V. G., Vetrivel, P., Lee, H. J., Kim, S. M., Ha, S. E., Murugesan, R., Kim, E. H., Heo, J. D., & Kim, G. S. (2020). Comparative proteomic analysis uncovers potential biomarkers involved in the anticancer effect of Scutellarein in human gastric cancer cells. Oncology reports, 44(3), 939–958. https://doi.org/10.3892/or.2020.7677 DOI: https://doi.org/10.3892/or.2020.7677

Spiegel, M., Marino, T., Prejanò, M., & Russo, N. (2022). On the Scavenging Ability of Scutellarein against the OOH Radical in Water and Lipid-like Environments: A Theoretical Study. Antioxidants (Basel, Switzerland), 11(2), 224. https://doi.org/10.3390/antiox11020224 DOI: https://doi.org/10.3390/antiox11020224

Sun, C. Y., Zhu, Y., Li, X. F., Wang, X. Q., Tang, L. P., Su, Z. Q., Li, C. Y., Zheng, G. J., & Feng, B. (2018). Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways. Frontiers in pharmacology, 9, 92. https://doi.org/10.3389/fphar.2018.00092 DOI: https://doi.org/10.3389/fphar.2018.00092

Sun, C., Li, C., Li, X., Zhu, Y., Su, Z., Wang, X., He, Q., Zheng, G., & Feng, B. (2018). Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo. Journal of Cancer, 9(18), 3247–3256. https://doi.org/10.7150/jca.25921 DOI: https://doi.org/10.7150/jca.25921

Sung, N. Y., Kim, M. Y., & Cho, J. Y. (2015). Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(5), 441–449. https://doi.org/10.4196/kjpp.2015.19.5.441 DOI: https://doi.org/10.4196/kjpp.2015.19.5.441

Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., Jr, & Kinzler, K. W. (2013). Cancer genome landscapes. Science (New York, N.Y.), 339(6127), 1546–1558. https://doi.org/10.1126/science.1235122 DOI: https://doi.org/10.1126/science.1235122

Xiong, L. L., Du, R. L., Xue, L. L., Jiang, Y., Huang, J., Chen, L., Liu, J., & Wang, T. H. (2020). Anti-colorectal cancer effects of scutellarin revealed by genomic and proteomic analysis. Chinese medicine, 15, 28. https://doi.org/10.1186/s13020-020-00307-z DOI: https://doi.org/10.1186/s13020-020-00307-z

Zeng, S., Chen, L., Sun, Q., Zhao, H., Yang, H., Ren, S., Liu, M., Meng, X., & Xu, H. (2021). Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade. European journal of pharmacology, 906, 174253. https://doi.org/10.1016/j.ejphar.2021.174253 DOI: https://doi.org/10.1016/j.ejphar.2021.174253

Zhu, X. Z., Li, X. Y., & Liu, J. (2004). Recent pharmacological studies on natural products in China. European journal of pharmacology, 500(1-3), 221–230. https://doi.org/10.1016/j.ejphar.2004.07.027 DOI: https://doi.org/10.1016/j.ejphar.2004.07.027

Aktar, M. A., Bhuia, M. S., Chowdhury, R., Biswas, S., Sanzida, M. R., Sonia, F. A., ... & Islam, M. T. (2024a). Anticancer activity of Nigella sativa and its bioactive compounds: An update. Pharmacological Research-Natural Products, 100100. https://doi.org/10.1016/j.prenap.2024.100100 DOI: https://doi.org/10.1016/j.prenap.2024.100100

Eity, T. A., Bhuia, M. S., Chowdhury, R., Ahmmed, S., Salehin Sheikh, Akter, R., & Islam, M. T. (2024). Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono- or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms. Journal of tropical medicine, 2024, 5594462. https://doi.org/10.1155/2024/5594462 DOI: https://doi.org/10.1155/2024/5594462

Aktar, A., Bhuia, S., Chowdhury, R., Ferdous, J., Khatun, M., Hasan, S. A., Mia, E., Hasan, R., & Islam, M. T. (2024). An Insight of Plant Source, Toxicological Profile, and Pharmacological Activities of Iridoid Loganic Acid: A ComprehensiveReview. Chemistry & biodiversity, 21(12), e202400874. https://doi.org/10.1002/cbdv.202400874 DOI: https://doi.org/10.1002/cbdv.202400874

Sang Eun, H., Seong Min, K., Ho Jeong, L., Vetrivel, P., Venkatarame Gowda Saralamma, V., Jeong Doo, H., Eun Hee, K., Sang Joon, L., & Gon Sup, K. (2019). Scutellarein Induces Fas-Mediated Extrinsic Apoptosis and G2/M Cell Cycle Arrest in Hep3B Hepatocellular Carcinoma Cells. Nutrients, 11(2), 263. https://doi.org/10.3390/nu11020263 DOI: https://doi.org/10.3390/nu11020263