Anticancer Activity of Scutellarein Against Several Cancer Types with Possible Mechanisms: A Mini Review

Imam Hossen  Rakib; Rakib  Hossan; Md. Sakib Al Hasan; Noshin Tasnim   Yana; Fowjia Ahmed  Safa; Umme Habiba Sumaya

doi:10.71193/jpci.20250005

Authors

Imam Hossen Rakib Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0003-2552-8952
Rakib Hossan Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0003-2552-8952
Md. Sakib Al Hasan Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0004-7560-4041
Noshin Tasnim Yana Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author
Fowjia Ahmed Safa Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0002-8189-1134
Umme Habiba Sumaya Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0000-2291-766X

DOI:

https://doi.org/10.71193/jpci.20250005

Keywords:

Scutellarein, Anti-cancer, Proliferation, Flavone

Abstract

Scutellarein (STN), a bioactive flavone found in various medicinal plants such as Scutellaria baicalensis and Scutellaria lateriflora. It has a variety of pharmacological actions, including anticancer properties. This study explores STN’s anticancer activity against various cancer cell lines. A literature review was conducted using databases such as PubMed, ScienceDirect, and Google Scholar, focusing on research evaluating STN’s anticancer efficacy. The results showed that STN has significant anticancer properties against various types of cancer, such as blood, colon, colorectal, gastric, liver, lung, ovarian, and renal cancers. STN reduces cell growth by cell cycle arrest, triggers apoptosis through caspase activation, and inhibits metastasis by suppressing mitochondrial membrane potential (MMP) and epithelial mesenchymal transition (EMT) markers. It modulates important pathways such as ERK, Wnt/β-catenin, and PI3K/Akt/NF-κB. Together, these systems prevent the growth and metastasis of cancer cells. The compound has exhibited prominent cytotoxicity in diverse cancer cell lines.