Anticancer activity of Magnifera indica through the caspase activation: A short review

Sumaya Akter Bithi; Afiya  Ajmee; Md Faisal  Amin; Moushumi Afroza  Mou; Rituparna Biswas  Suma; Rakib  Hossan; Md. Arif  Hossain; Abida  Sultana

doi:10.71193/jpci.20250004

Authors

Sumaya Akter Bithi Gopalganj Science and Technology University, Gopalganj 8100 Author https://orcid.org/0009-0009-9697-9551
Afiya Ajmee Gopalganj Science and Technology University, Gopalganj 8100 Author
Md Faisal Amin The University of Texas Rio Grande Valley Author https://orcid.org/0009-0009-9274-1335
Moushumi Afroza Mou St. John’s University Author https://orcid.org/0009-0001-9267-9860
Rituparna Biswas Suma Gopalganj Science and Technology University, Gopalganj 8100 Author https://orcid.org/0009-0006-1018-807X
Rakib Hossan Gopalganj Science and Technology University, Gopalganj 8100 Author https://orcid.org/0009-0002-7692-2266
Md. Arif Hossain Gopalganj Science and Technology University, Gopalganj 8100 Author https://orcid.org/0009-0005-1223-3877
Abida Sultana Gopalganj Science and Technology University, Gopalganj 8100 Author https://orcid.org/0009-0009-6439-0347

DOI:

https://doi.org/10.71193/jpci.20250004

Keywords:

Cancer, Caspase activation, Magnifera indica, Natural sources

Abstract

Cancer is one of the major global health concerns. Although several treatment processes are available for cancer, they have many side effects. Several natural plants, like Mangifera indica, have gained attention for cancer treatment due to their fewer side effects. This paper aims to review the anticancer effects of M. indica by analyzing its role in activating caspase. A literature review was carried out using databases like PubMed, Science Direct, and Google Scholar directly, with a focus on in vitro and in vivo investigations to demonstrate caspase activation in cancer treatment. Our findings revealed that M. indica extracts significantly enhance caspase-3, -8, and -9 activity, which induces apoptosis in breast, cervical, and colon cancer cells. This plant extract fights against cancer by stopping the spread of cancer cells and their growth. M. indica exhibited significant anti-cancer activity via caspase activation, proving its potential as a natural anti-cancer therapy.