Phytochemical Profiling and Evaluation of Antioxidant, Antimicrobial, and Thrombolytic Activities of Ethanolic Extract of Tarenna campaniflora Leaves

Md. Mizan; Md. Shawon  Miah; Umme Habiba Sumaya; Noshin Tasnim Yana; Mst Muslima Khatun; Proma  Mandal; Ali Mohamod Wasaf  Hasan; Mohammed Burhan Uddin; Md Abu Sayeed; Khadija Akter; Mohammad  Aslam; Emon Mia; Md. Sakib  Al Hasan

doi:10.71193/jpci.20250011

Authors

Md. Mizan Department of Pharmacy, Dhaka International University, Satarkul, Badda, Dhaka-1212, Bangladesh Author
Md. Shawon Miah Department of Pharmacy, Dhaka International University, Satarkul, Badda, Dhaka-1212, Bangladesh Author
Umme Habiba Sumaya Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0000-2291-766X
Noshin Tasnim Yana Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0006-3083-0533
Mst Muslima Khatun Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0004-1801-1928
Proma Mandal Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0009-9115-1149
Ali Mohamod Wasaf Hasan Department of Pharmacy, Mawlana Bhashani Science and Technology University. Santosh, Tangail Author https://orcid.org/0000-0003-4461-5878
Mohammed Burhan Uddin Department of Pharmacy, East West University, Aftabnagar, Dhaka-1212, Bangladesh Author https://orcid.org/0009-0007-4674-6448
Md Abu Sayeed Department of Pharmacy, Mawlana Bhashani Science and Technology University. Santosh, Tangail Author https://orcid.org/0000-0002-3870-9408
Khadija Akter Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0000-6373-6929
Mohammad Aslam Department of Biochemistry and Molecular Biology, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author
Emon Mia Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0007-7390-056X
Md. Sakib Al Hasan Department of Pharmacy, Gopalganj Science and Technology University Author https://orcid.org/0009-0004-7560-4041

DOI:

https://doi.org/10.71193/jpci.20250011

Keywords:

Tarenna campaniflora, phytochemical screening, anti-microbial activity, thrombolytic activity

Abstract

Discovery of the genus Tarenna campaniflora and its traditional uses was obtained by living in forest or semi-forest areas and by close observations of the indigenous populations. This study evaluated the phytochemical constituents, antioxidant potential, antimicrobial efficacy, and thrombolytic activity of ethanolic leaf extract of Tarenna campaniflora. Qualitative phytochemical screening revealed the presence of various bioactive metabolites. DPPH assay demonstrated notable antioxidant activity (IC₅₀ = 0.877 µg/mL), comparable to ascorbic acid (IC₅₀ = 0.839 µg/mL). Disc diffusion assay showed antimicrobial activity, with the highest inhibition against Escherichia coli (18 mm). The extract also exhibited clot lysis (22.42%), compared to streptokinase (31.17%). The findings support the therapeutic potential of T. campaniflora, warranting further pharmacological investigations.

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