Recent Advances in Plant‑Derived Anti‑Cancer Compounds: Promising Leads

Akhtar, U., Gulzar, A., Saleem, M., Shahid, A., Usman, N., Usman, Z., ... & Rasheed, W. (2025). Phytochemicals as Cancer Immunotherapeutics: Bridging Natural Compounds and Advanced Treatment Strategies. Sch Acad J Biosci, 1, 164-176. DOI: https://doi.org/10.36347/sajb.2025.v13i01.017

Bhuia, M. S., Chowdhury, R., Ara, I., Mamun, M., Rouf, R., Khan, M. A., Uddin, S. J., Shakil, M. A. K., Habtemariam, S., Ferdous, J., Calina, D., Sharifi-Rad, J., & Islam, M. T. (2024). Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms. Fitoterapia, 175, 105896. https://doi.org/10.1016/j.fitote.2024.105896 DOI: https://doi.org/10.1016/j.fitote.2024.105896

Bhuia, M. S., Chowdhury, R., Sonia, F. A., Kamli, H., Shaikh, A., El-Nashar, H. A. S., El-Shazly, M., & Islam, M. T. (2023a). Anticancer Potential of the Plant-Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches. Chemistry & biodiversity, 20(9), e202300847. https://doi.org/10.1002/cbdv.202300847 DOI: https://doi.org/10.1002/cbdv.202300847

Bhuia, M. S., Wilairatana, P., Chowdhury, R., Rakib, A. I., Kamli, H., Shaikh, A., Coutinho, H. D. M., & Islam, M. T. (2023b). Anticancer Potentials of the Lignan Magnolin: A Systematic Review. Molecules (Basel, Switzerland), 28(9), 3671. https://doi.org/10.3390/molecules28093671 DOI: https://doi.org/10.3390/molecules28093671

Bhuia, M. S., Wilairatana, P., Ferdous, J., Chowdhury, R., Bappi, M. H., Rahman, M. A., Mubarak, M. S., & Islam, M. T. (2023c). Hirsutine, an Emerging Natural Product with Promising Therapeutic Benefits: A Systematic Review. Molecules (Basel, Switzerland), 28(16), 6141. https://doi.org/10.3390/molecules28166141 DOI: https://doi.org/10.3390/molecules28166141

Biswas, P., Mathur, D., Dinesh, J., Dinesh, H. K., & Desai, B. M. A. (2025, February). Computational analysis using multi-ligand simultaneous docking of withaferin A and garcinol reveals enhanced BCL-2 and AKT-1 inhibition. In 2025 International Conference on Innovation in Computing and Engineering (ICE) (pp. 1-6). IEEE. DOI: https://doi.org/10.1109/ICE63309.2025.10984324

Chowdhury, R., Bhuia, M. S., Wilairatana, P., Afroz, M., Hasan, R., Ferdous, J., Rakib, A. I., Sheikh, S., Mubarak, M. S., & Islam, M. T. (2024). An insight into the anticancer potentials of lignan arctiin: A comprehensive review of molecular mechanisms. Heliyon, 10(12), e32899. https://doi.org/10.1016/j.heliyon.2024.e32899 DOI: https://doi.org/10.1016/j.heliyon.2024.e32899

Dipa, C. D., Hossain, S., Chy, M. M. K., Rahman, M. S. F., Kayes, T., Easha, A. M., ... & Sarkar, B. K. (2025). In silico exploration of anticancer plant phytochemicals for EGFR-targeted lung cancer therapy. Scientific Reports, 15(1), 27809. DOI: https://doi.org/10.1038/s41598-025-10412-4

Ferdous, J., Bhuia, M. S., Chowdhury, R., Rakib, A. I., Aktar, M. A., Al Hasan, M. S., Melo Coutinho, H. D., & Islam, M. T. (2024). Pharmacological Activities of Plant-Derived Fraxin with Molecular Mechanisms: A Comprehensive Review. Chemistry & biodiversity, 21(5), e202301615. https://doi.org/10.1002/cbdv.202301615 DOI: https://doi.org/10.1002/cbdv.202301615

Hadkar, V. M., Mohanty, C., & Selvaraj, C. I. (2024). Biopolymeric nanocarriers in cancer therapy: unleashing the potency of bioactive anticancer compounds for enhancing drug delivery. RSC advances, 14(35), 25149-25173. DOI: https://doi.org/10.1039/D4RA03911D

Hashim, G. M., Shahgolzari, M., Hefferon, K., Yavari, A., & Venkataraman, S. (2024). Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals. Bioengineering, 12(1), 7. DOI: https://doi.org/10.3390/bioengineering12010007

Kangra, K., Kakkar, S., Mittal, V., Kumar, V., Aggarwal, N., Chopra, H., ... & Garg, V. (2025). Incredible use of plant-derived bioactives as anticancer agents. RSC advances, 15(3), 1721-1746. DOI: https://doi.org/10.1039/D4RA05089D

Saha, A., Desai, B. M. A., & Biswas, P. (2024, October). Multi-ligand simultaneous docking analysis of Moringa oleifera phytochemicals reveals enhanced BCL-2 inhibition via synergistic action. In 2024 5th International Conference on Biomedical Engineering (IBIOMED) (pp. 51-56). IEEE. DOI: https://doi.org/10.1109/iBioMed62485.2024.10875829

Shukla, S., Shukla, A. K., Upadhyay, A. M., Ray, N., Fahad, F. I., Nagappan, A., ... & Mongre, R. K. (2025). Molecular insight and antioxidative therapeutic potentials of plant-derived compounds in breast cancer treatment. Onco, 5(2), 27. DOI: https://doi.org/10.3390/onco5020027