Antioxidant Activity of Promising Probiotic Potential Lactobacillus Plantarum: A Review

Jannatul Ferdous; Raihan Chowdhury; Md. Sarafat Ali; Abu Hashem

doi:10.71193/jcid.20250002

Authors

Jannatul Ferdous Microbial Biotechnology Division, National Institute of Biotechnology, Ganakbari, Ashulia, Savar, Dhaka 1349, Bangladesh Author https://orcid.org/0009-0000-8478-5818
Raihan Chowdhury Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0009-0007-0672-6581
Md. Sarafat Ali Department of Biotechnology and Genetic Engineering, Gopalganj Science and Technology University, Gopalganj 8100, Bangladesh Author https://orcid.org/0000-0003-1969-7883
Abu Hashem Microbial Biotechnology Division, National Institute of Biotechnology, Ganakbari, Ashulia, Savar, Dhaka 1349, Bangladesh Author https://orcid.org/0000-0002-0033-7346

DOI:

https://doi.org/10.71193/jcid.20250002

Keywords:

Lactobacillus plantarum, Probiotic potential, Antioxidant activity, Free radical scavenging, Oxidative stress

Abstract

Oxidative stress is a key factor in chronic illnesses. Lactobacillus plantarum is a promising probiotic bacteria with considerable antioxidant capacity by boosting enzymatic defenses, making it a promising candidate for enhancing human health. The aim of this study is to evaluate the antioxidant activity of L. plantarum and its potential synergistic effects with other bioactive compounds. From this study, L. plantarum exhibits significant antioxidant activity through multiple pathways, including scavenging free radicals and modulating oxidative stress responses. L. plantarum might enhance the enzymatic activity such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH). Furthermore, it scavenges free radicals including DPPH•, ABTS•+, and •OH while lowering malondialdehyde (MDA) levels, therefore preventing lipid peroxidation. Notably, the synergistic effects observed include enhanced free radical neutralization and improved cellular defense mechanisms. L. plantarum might be a natural antioxidant source for functional foods and medicinal applications that boost overall health and reduce oxidative stress-related illnesses. Additional research is needed to understand the strain-specific processes, clinical effectiveness, functional food uses, and molecular relationships of L. plantarum.

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